Aldosterone adrenal cortex4/9/2023 ![]() Aldosterone synthase expresses almost entirely in the adrenal cortex and exclusively in the zona glomerulosa layer. In addition, aldosterone is synthesized by aldosterone synthase, an enzyme encoded by CYP11B2. In the zona glomerulosa, 3β- hydroxysteroid dehydrogenase, 21-hydroxylase and 11β-hydroxylase are the major enzymes which are involved in the aldosterone synthesis. Cholesterol travels across the mitochondrial membrane. The hormones of the adrenal cortex are steroid derivatives, synthesized from cholesterol. The medulla stores and secretes catecholamines. The cortex makes up about 80% to 90% of the adrenal gland. ![]() The outermost zona glomerulosa, which produces mineralocorticoids the zona fasciculata, which is responsible for glucocorticoid production and the inner zona reticularis, which synthesizes androgens. The cortex is further divided into three zones. Welcome to this Pearl of Laboratory Medicine on “ Aldosterone and Renin” Slide 2:Īnatomically, the adrenal glands are divided into two distinct parts, the medulla, the inner layer and the cortex, the outer layer. I am an assistant professor and lab director at Ohio State University Wexner Medical Center. ![]()
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